87 Patient population and data collection The identification of patients to be included in the review followed a hierarchical approach. We extracted all medical records belonging to patients with a discharge diagnosis of sepsis in the Hospital Information System for the complete year of 2016. From these, we selected those records that used the International Classification of Diseases-tenth revision (ICD-10) code for sepsis, after which we selected those records compatible with the Sepsis-2 definition of sepsis. The final selection step limited the study population to adults (17 years of age or older). We hand-searched the selected medical records for information with regards to demographic characteristics, underlying condition (Charlson Comorbidity Index), results of cultures and antimicrobial susceptibility tests, length of hospital stay, source of infection leading to sepsis, and antibiotic treatment received. Information on culture and AST was extracted from the Hospital Information System if not present in the medical record, which might have happened if the patient died or was discharged before these results were received from the laboratory. The extracted information followed a pre-defined protocol and was reviewed by two independent physicians. Sumber: Ginting et al. (2020) b. Methods Design and sampling
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